A motorcyclist has died after he was struck by a ute in the Bacchus Marsh suburb of Maddingley.
The incident occurred on Woolpack Road at about 7.15pm on Wednesday, with the rider who is yet to be formally identified dying at the scene.
The driver and one of the passengers are assisting police with enquiries, while the second passenger fled on foot and is still on the run.
Homicide Squad and Major Collision Investigation Unit detectives are investigating the exact circumstances surrounding the collision and are asking anyone who witnessed the incident or has dash-cam vision of the vehicles in the lead up to the collision.
Anyone with information is asked to contact Crime Stoppers on 1800 333 000.