A woman in her 70s has been flown to the Royal Melbourne Hospital after a 2-car accident along Ballarat's Avenue of Honour.
The first calls came in at 1.29pm to an area in Cardigan about 600m from the Skipton Rail Trail.
A Ballarat CFA rescue crew have cut a person out of a grey Corolla sedan.
Paramedics say the woman has upper body injuries and is in a serious but stable condition
Remembrance Drive has been closed in both directions for much of the afternoon between Lucas and Cardigan.