Heavily armed police have converged on Federation University in central Ballarat.
The operation, which police have described as a safety check, involves both uniformed and plain-clothed officers.
No threat to community has been issued at this stage but people are being urged to avoid the area.
Onlooker Fiona says multiple streets have been cordoned off.
"Two to three city blocks have been shut down, there are highway patrol people at roundabouts and multiple police," she said.